© 2016 by the Paszek Research Group

Selected Publications

  1. Cheng Z*, Shurer CR*, Gupta VK, Chuang G, Hui H, Paszek MJ (2017). Solid Surface Stresses Direct Cellular Behaviors Through Integrin-Based Mechanotransduction.  In review.  *Authors contributed equally to this work.

  2. Shurer CR*, Colville MJ*, Gupta VK, Head SE, Kai F, Lakins J, and Paszek MJ (2017).  Genetically Encoded Toolbox for Glycocalyx Engineering: Tunable Control of Cell Adhesion, Survival, and Cancer Cell Behaviors. In Review. *Authors contributed equally to this work.

  3. Gandhi J, Koch D*, and Paszek MJ*.  Equilibrium Structure and Mechanics of the Cellular glycocalyx. In preparation. *Co-corresponding authors.  

  4. Colville MJ, Singh A, Zipfel WR, and Paszek MJ. High-speed Scanning Angle Interference Microscopy. In preparation.

  5. Paszek MJ, Dufort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon A, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM.  2014. The cancer glycocalyx mechanically primes integrin-mediated growth and survival.  Nature 511(7509): 319-25.  Highlighted in:

    • Ewald AJ and Egeblad M, Nature (2014).

    • Osgood MM, Cornell Chronicle (2014).

    • Science Daily (2014)

    • Today’s Dietician

    • Science World Report

    • Natural Medicine

    • Peritoneal Dialysis International

    • Oncology Nurse Advisor

    • Counsel and Heal

  6. Dufort CC and Paszek MJ.  2014.  Nanoscale cellular imaging with scanning angle interference microscopy. Methods in Cell Biology – Quantitative Fluorescence Microscopy.

  7. Stehbens SJ, Paszek MJ, Pemble H, Ettinger A, Gierke S, and Wittmann, T. 2014. CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover Nature Cell Biology 16: 561-73.

  8. Rubashkin MG, Cassereau L, Bainer R, DuFort CC, Yui Y, Oakes PW, Ou G, Paszek MJ, Davidson MW, Chen YY, Gardel ML, Weaver VM.  2014. Force engages vinculin and promotes tissue transformation by enhancing PI3-kinase activation of Phosphatidylinositol (3,4,5)-triphosphate.  Cancer Research 74: 4597-4611.

  9. Burnette DT, Shao L, Ott C, Pasapera AM, Fischer RS, Baird MA, Der Loughian C, Delanoe-Ayari, Paszek MJ, Davidson MW, Betzig E, Lippincott-Schwartz J.  2014. A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells.  Journal of Cell Biology 205: 83-96.

  10. Paszek MJ, Dufort C, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, and Weaver VM.  2012.  Scanning angle interference microscopy reveals cell dynamics at the nano-scale.  Nature Methods 9: 825-7. Highlighted in Faculty of 1000 Evaluations: http://f1000.com/prime/717977172

  11. Dufort C, Paszek MJ, and Weaver VM. 2011. Balancing forces: architectural control of mechanotransduction (Review).  Nature Reviews Molecular Cell Biology 12: 308-19.

  12. Paszek M and Weaver V. 2010.  Biophysics.  Enforcing order on signaling. Science 327: 1335-36.  (Commentary article)

  13. Paszek MJ, Boettiger D, Weaver VM, and Hammer DA. 2009.  Integrin clustering is driven by mechanical resistance from the glycocalyx and substrate.  PLoS Computational Biology 5: e1000604.

  14. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A., Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, and Weaver VM.  2005. Tensional homeostasis and the malignant phenotype.  Cancer Cell 8: 241-54.  Cited 2000 times and highlighted in:

    • Kinerstis PA, “Editors’s Choice,” Science, 309: 1967 (2005)

    • Comoglio PM and Trusolina L, “News and Views,” Nature Medicine, 11: 1156-57 (2005)

    • Huang S and Ingber DE, “Previews,” Cancer Cell, 8: 175-6

    • Faculty of 1000 Evaluations: http://f1000.com/prime/1031255

    • “Science News,” ScienceDaily, Sept. 26. (2009)

  15. Paszek MJ and Weaver VM. 2004. The tension mounts: mechanics meets morphogenesis and malignancy (Review). Journal of Mammary Gland Biology and Neoplasia 9: 325-42.

 

Recent Invited Talks

 

  1. Paszek MJ. “Slimy forces: the cancer cell glycocalyx mechanically primes integrin dependent growth and survival.”  Biophysics Seminar, Cornell University, Ithaca, NY (2014).

  2. Paszek MJ. “Mechanobiology of the cellular glycocalyx” Biomedical Sciences Departmental Seminar, Cornell University, Ithaca, NY (2014).

  3. Paszek MJ. “Mechanobiology of the cellular glycocalyx” Cell and Developmental Biology Seminar, Vanderbilt School of Medicine, Nashville, TN (2015).

  4. Paszek MJ. “Mechanobiology of the glycocalyx” Gordon Research Conference: Fibronectin, Integrins, and Related Molecules, Lucca, Italy (2015).

  5. Paszek MJ. “Mechanobiology of the metastatic glycocalyx”, Japanese Association for Metastatic Research Annual Meeting, Osaka, Japan (2015). Highlights:

    • Invited keynote speaker

  6. Paszek MJ. “Mechanobiology of the glycocalyx” Mucin Meeting 2015, Cambridge, United Kingdom (2015).

  7. Paszek MJ. “Mechanobiology of the cellular glycocalyx” Physics of Living Matter 2016 Conference, Cambridge, United Kingdom (2016).

  8. Paszek MJ. “Mechanobiology of the cellular glycocalyx” Center for NanoScience Workshop: Nanoscale Matter – Novel Concepts and Functions, Venice, Italy (2016).

  9. Paszek MJ. “Mechanobiology of the cellular glycocalyx” CellMatrix, Berlin, Germany (2016).

  10. Paszek MJ. “Glycoproteins shape cellular form and function” Cornell CBE Graduate Research Symposium, Cornell University, Ithaca, NY (2017).

    • Invited as keynote speaker by CBE graduate students​

 

Recent Presentations (Group Members)

 

  1. Hollander MJ and Paszek MJ. “Effect of Galectin on Microvesicle Formation,” Cornell Undergraduate Research Board (CURB; Poster), Cornell University, Ithaca, NY (2013).

  2. Colville MJ, Singh A, Zipfel WR, and Paszek MJ. Axial Nanoscopy at the Speed of Life:  Developing a next-generation Scanning Angle Interference Microscope, Cornell Annual Biophysics Symposium (Platform Talk), Cornell University, Ithaca, NY (2015).

  3. Shurer CR and Paszek MJ. “Deformable, optically transparent elastomers for super-resolution microscopy and micro-fabricated devices,” CBE Graduate Research Symposium (Poster), Cornell University, Ithaca, NY (2015).

  4. Roberts LM, Shurer CR, Hollander MJ, Paszek MJ. “Muc1-induced Microvesicle Shedding in Breast Cancer: A Biophysical Phenomenon,” Academic Research & Leadership Symposium at the National Society of Black Engineers Conference (Poster), Boston, MA (2016).

  5. Roberts LM, Shurer CR, Hollander MJ, Paszek MJ. “Muc1-induced Microvesicle Shedding in Breast Cancer: A Biophysical Phenomenon,” National Academies of Science Ford Foundation Conference (Poster), Washington DC (2016).

  6. Gupta, VK., Colville MJ., and Paszek MJ. “Development of a widefield fluorescence microscopy system for long-term live-cell imaging,” Cornell Undergraduate Research Board (CURB; Poster), Cornell University, Ithaca, NY (2016).

  7. Yin R, Roberts LM, Shurer CR, and Paszek MJ. “Impact of Gal3 on Microvesicle Shedding,” Cornell Undergraduate Research Board (CURB; Poster), Cornell University, Ithaca, NY (2016).

  8. Gupta D, Colville MJ, Paszek MJ, "Lipid Encapsulation of Fluorescent Nanodiamonds for Single Particle Tracking of the Clathrin-Mediated Endocytic Pathway," ASEE St. Lawrence Section Spring 2016 Conference, Cornell University, Ithaca, NY (2016).

  9. Shurer CR and Paszek MJ. “Glycosylation dynamically tunes the biophysical properties of the cancer cell glycocalyx,” Biophysics Graduate Student Seminar Series (Platform Talk), Cornell University, Ithaca, NY (2016).

  10. Colville MJ, Singh A, Zipfel WR, and Paszek MJ. “Developments and applications in live cell Scanning Angle Interference Microscopy,” Biophysics Graduate Student Seminar Series (Platform Talk), Cornell University, Ithaca, NY (2016).

  11. Pan H and Paszek MJ. “Can Physiological Crowding affect Cell Membrane Signaling?,” Biophysics Graduate Student Seminar Series (Platform Talk), Cornell University, Ithaca, NY (2016).

  12. Colville MJ, Singh A, Zipfel WR, and Paszek MJ. “High-Speed Nanometer Scale Imaging with Scanning Angle Interference Microscopy (SAIM),” Gordon Research Conference Single Molecule Approaches to Biology (Poster), Hong Kong (2016).

  13. Shurer CR and Paszek MJ. “Glycosylation dynamically tunes the biophysical properties of the cancer cell glycocalyx,” American Association for Cancer Research, Engineering and Physical Sciences in Oncology (Poster), Boston, MA (2016).

  14. Holcomb Z, Roberts LM, and Paszek MJ. “The Impact of Mucins at the Membrane Level In Breast Cancer,” CHAMPS Summer Scholarship Program (Platform Talk), Cornell University, Ithaca, NY (2016).

  15. Roberts LM, Shurer CR, Hollander M, Paszek MJ. “Muc1-induced Microvesicle Shedding in Breast Cancer: A Biophysical Phenomenon,” Biomedical Engineering Society (BMES) Annual Meeting, Minneapolis, (2016).

  16. Pan H and Paszek MJ. “Can Physiological Crowding affect Cell Membrane Signaling?,” Cornell 2nd Annual Biophysics Symposium (Poster), Cornell University, Ithaca, NY (2016).

  17. Gandhi JG, Paszek MJ, Koch DL. “Steady state response of the glycocalyx to mechanical compression,” Cornell 2nd Annual Biophysics Symposium (Poster), Cornell University, Ithaca, NY (2016).

  18. Colville MJ, Shurer CR, Enoki TA, Feigenson GW, Paszek MJ. “An Entropic Mechanism for the Biogenisis of Highly Curved Plasma Membrane Structures,” Cornell 2nd Annual Biophysics Symposium (Platform Talk), Cornell University, Ithaca, NY (2016).

  19. Shurer CR, Head SE, Colville MJ, Gupta VK, and Paszek MJ.  “Glycosylation Dynamically Tunes the Biophysical Properties of the Cancer Cell Surface,” AICHE Annual Meeting (Platform Talk), San Francisco, CA (2016).

  20. Cheng Z, Shurer CR, Chuang G, Hui H, Paszek MJ.  “Cells Sense and Respond to the Surface Tension of Biomaterials through Integrin-based Mechanotransduction,” AICHE Annual Meeting (Poster), San Francisco, CA (2016).

  21. Shurer CR, Colville MJ, Head SE, Gupta VK, and Paszek MJ.  “Glycosylation Dynamically Tunes the Biophysical Properties of the Cancer Cell Surface,” Cornell CBE Graduate Research Symposium (Platform Talk), Cornell University, Ithaca, NY (2017).

  22. Cheng Z, Shurer CR, Hui H, Paszek MJ.  “Cells Sense and Respond to the Surface Tension of Biomaterials through Integrin-based Mechanotransduction,” Cornell CBE Graduate Research Symposium (Platform Talk), Cornell University, Ithaca, NY (2017).

    • Awarded best talk as voted by the faculty of the Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University

  23. ​Gandhi JG, Koch DL, Paszek MJ. “Equilibrium mechanical response of the glycocalyx,” Cornell CBE Graduate Research Symposium (Poster), Cornell University, Ithaca, NY (2017).

  24. Roberts LM, Shurer CR, Hollander M, Enoki, T, and Paszek MJ.  “Entropic Control of Microvesicle Shedding in Breast Cancer,” Cornell Center on the Physics of Cancer Metabolism, Physical Sciences in Oncology Retreat (Poster), Cornell University (2017).

  25. Shurer CR, Colville MJ, Head SE, Gupta VK, and Paszek MJ. "A Genetically Encoded Toolbox for Glycocalyx Engineering: Tunable Control of Cell Adhesion, Survival, and Motility,” Cornell Center on the Physics of Cancer Metabolism, Physical Sciences in Oncology Retreat (Poster), Cornell University (2017).

    • Awarded best poster.​

  26. Gandhi JG, Koch DL, Paszek MJ. “Equilibrium mechanical response of the glycocalyx,” Cornell Center on the Physics of Cancer Metabolism, Physical Sciences in Oncology Retreat (Poster), Cornell University, Ithaca, NY (2017).

  27. Kuo JCH, Shurer CR, Colville MJ, Roberts LM and Paszek MJ. “Visualising cancer cell nanostructures with expansion microscopy,” Cornell Center on the Physics of Cancer Metabolism, Physical Sciences in Oncology Retreat (Poster), Cornell University (2017).

  28. Gandhi JG, Koch DL, Paszek MJ. “Equilibrium biomechanical response of the glycocalyx,” Biophysical Society Annual Meeting (Poster), New Orleans, LA (2017).